Research Institute Brainclinics:

Applied Neuroscience, Neuromodulation and Personalized Medicine for ADHD and Depression.

Brainclinics was established in 2001 as a research institute specialized in Applied Neuroscience, Neuromodulation, and Personalized Medicine with a focus on ADHD and depression. More scientific background on Neurofeedback in ADHD and rTMS in depression can be found here. For more client related information on these topics also see our psychology practice.

Brainclinics conducts applied brain research (Applied Neuroscience) using of techniques such as EEG and QEEG, Actigraphy, Event Related Potentials (ERPs) and neuropsychological assessments.

iSPOT study of ADHD and Depression

Currently Research Institute Brainclinics is one of the international groups involved in the  iSPOT studies, which stands for International Study to Predict Optimised Treatment Response in ADHD (iSPOT-A) and Depression (iSPOT-D). This is the largest ever trial into the potential of Personalized Medicine in more than 2000 depressed patients (who will be prescribed an antidepressant), and more than 500 children with ADHD prescribed with methylphenidate (eg Ritalin).

For the iSPOT-A study we are still seeking healthy children (boys) between 6-17 years of age (healthy children do not need to use medication). For more information see the section iSPOT.

Applied Neuroscience

In the "Applied Neuroscience" section the history of these techniques and a historical review on diagnosis and prognosis of ADHD and Depression are presented. The first section describes the history from EEG to QEEG. The second part further elaborates on the EEG as a biomarker or endophenotype, followed by a historical overview of neurophysiological studies in ADHD and depression and an overview of models and theories about the interpretation of EEG and QEEG. Finally, some EEG examples for  subtypes can be found such as a Low-Voltage EEG and Beta spindles.

Personalized Medicine for ADHD and Depression

In the recent years Brainclinics has specialized to further explore the use of neurophysiological techniques in predicting treatment outcomes to different treatments such as psychostimulants (e.g. Ritalin), antidepressants (e.g. SSRIs), rTMS for depression and Neurofeedback in ADHD. This development is also called Personalized Medicine. Under the section Personalized Medicine and Neuromodulation, more information can be found on the current status of treatment efficacy in psychiatry and new developments in this area. In the section on ADHD a summary of the current state of research on Personalized Medicine in ADHD to various treatments is provided. In addition an explanatory model is proposed explaining how to interpret these different sub-types and how treatments for ADHD may be further improved based on this knowledge.  

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